Expression in Lung Epithelial Cells in System Is an Important Modulator of Gene Effector ExoU from the Type III Secretion
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Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection.
Pseudomonas aeruginosa is an important pathogen in immunocompromised patients and secretes a diverse set of virulence factors that aid colonization and influence host cell defenses. An important early step in the establishment of infection is the production of type III-secreted effectors translocated into host cells by the bacteria. We used cDNA microarrays to compare the transcriptomic respons...
متن کاملویژگیهای سیستم ترشحی نوع 3 در نمونههای سودوموناس ائروژینوزای جدا شده از بیماران مبتلا به سیستیک فیبروزیس
Abstract Background: Pseudomonas aeruginosalung infection is a major cause of morbidity and mortality in patients with cystic fibrosis (CF). The type III secretion system is an important and identified virulence determinant of P. aeruginosa that delivers effector proteins into targeted host cells. Three effector proteins have been described in P. aeruginosa: exoS, exoT, exoU. Unlike many studie...
متن کاملفراوانی ژنهای کد کننده سیتوتوکسینهای exoT، exoY، exoS وexoU سیستم ترشحی تیپ 3 در سودوموناس آئروجینوزا جدا شده از بیماران سوختگی
Background and Objective: Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial burn infections. Disease results from the production of numerous virulence factors, some of which are injected directly into the eukaryotic host cells via the type III secretion system (T3SS).The aim of this study was to determine the prevalence of cytotoxins encoding exoT, exoY, exoS and exoU genes...
متن کاملType III Secretion of ExoU Is Critical during Early Pseudomonas aeruginosa Pneumonia
UNLABELLED The Pseudomonas aeruginosa type III secretion system has been associated with poor outcomes in both animal models and human patients. Despite a large number of studies exploring the regulation of type III secretion in vitro, little is known about the timing of secretion during mammalian infection. Here we demonstrate that the exoU gene, which encodes the highly cytotoxic type III eff...
متن کاملPseudomonas aeruginosa infection of airway epithelial cells modulates expression of Kruppel-like factors 2 and 6 via RsmA-mediated regulation of type III exoenzymes S and Y.
Pseudomonas aeruginosa is an important opportunistic pathogen which is capable of causing both acute and chronic infections in immunocompromised patients. Successful adaptation of the bacterium to its host environment relies on the ability of the organism to tightly regulate gene expression. RsmA, a small RNA-binding protein, controls the expression of a large number of virulence-related genes ...
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تاریخ انتشار 2003